Principles of Electrospray Ionization
نویسندگان
چکیده
منابع مشابه
Principles of electrospray ionization.
Electrospray ionization is today the most widely used ionization technique in chemical and biochemical analysis. Interfaced with a mass spectrometer it allows the investigation of the molecular composition of liquid samples. With electrospray a large variety of chemical substances can be ionized. There is no limitation in mass which thus enables even the investigation of large noncovalent prote...
متن کاملDesorption Electrospray Ionization (DESI)
A new method of desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing electrosprayed charged droplets and ions of solvent onto the surface to be analyzed. The resulting mass spectra are similar to normal ESI mass ...
متن کاملElectrospray : Principles and Practice
The basic principles underlying the electrospray process are reviewed without recourse to detailed discussion of mechanisms. The essential features of the practical implementation of electrospray (at various solution Ñow rates) are described and the nature of the resultant gas-phase ion population is discussed. The generation by electrospray of multiply charged ions creates complications in tha...
متن کاملSolvent gradient electrospray for laser ablation electrospray ionization mass spectrometry.
Most electrospray based ambient ionization techniques, e.g., laser ablation electrospray ionization (LAESI), utilize a fixed spray solution composition. Complex samples often contain compounds of different polarity that exhibit a wide range of solubilities in the electrospray solvent. Thus, the fixed spray solution composition limits the molecular coverage of these approaches. Two-barrel theta ...
متن کاملUnraveling the mechanism of electrospray ionization.
Electrospray ionization (ESI) generates intact gas-phase ions from analytes in solution for mass spectrometric investigations. ESI can proceed via different mechanisms. Low molecular weight analytes follow the ion evaporation model (IEM), whereas the charged residue model (CRM) applies to large globular species. A chain ejection model (CEM) has been proposed for disordered polymers.
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2011
ISSN: 1535-9476
DOI: 10.1074/mcp.m111.009407